Abrin Toxicity and Bioavailability after Temperature and pH Treatment
نویسندگان
چکیده
منابع مشابه
Abrin Toxicity and Bioavailability after Temperature and pH Treatment
Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon. The temperature and pH stability of abrin was evaluated with an in vitro cell free translation (CFT) assay, a Vero cell culture cytotoxicity assay, and an in vivo mouse bioassay. pH treatment of abrin had no detrimental effect on its stability and...
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The oral and intraperitoneal (i.p.) toxicities to female BALB/c mice of ricin and abrin in phosphate-buffered saline (PBS), spring water, apple juice, and half-and-half (only oral) were examined after brief (2 h) and prolonged (11 to 13 days) storage. The ricin and abrin samples prepared in PBS had oral toxicities consistent with those previous studies, indicating oral and i.p. 50% lethal doses...
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ژورنال
عنوان ژورنال: Toxins
سال: 2017
ISSN: 2072-6651
DOI: 10.3390/toxins9100320